nonlinear regression curve fitting package (sigmoidal dose–response) (GraphPad Software Inc)
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nonlinear regression curve fitting package (sigmoidal dose–response)
![IC 50 and IC 90 values (μM) of anti-tumor drugs for monolayer and spheroid-cultured cells in a 96-well format (Fig. <xref ref-type=]()
S2 , n = 3). Each cell culture was performed at 37 °C in an atmosphere containing 5% CO 2 , and treated with various concentrations of drugs for 48 h. Cell viability was assessed using the MTS assay reagent (Promega). Data were analyzed using a nonlinear regression curve-fitting package in Prism 4 (GraphPad Software Inc.) (Fig. S2 ). The drugs tested included: docetaxel, a mitotic inhibitor; irinotecan, a topoisomerase I inhibitor; 5-fluorouracil (5-FU), a thymidylate synthase inhibitor; sunitinib, a multi-receptor tyrosine kinase (RTK) inhibitor; tirapazamine, a hypoxia-activated prodrug; and FX11, a lactate dehydrogenase inhibitor. Radial organization of each cell on the spheroidal culture dish (IWAKI) conferred resistance to the most of drugs tested." width="250" height="auto" />
Nonlinear Regression Curve Fitting Package (Sigmoidal Dose–Response), supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nonlinear+regression+(curve+fit)-boltzmann+sigmoidal/nonlinear+regression+curve+fitting+package++sigmoidal+dose+response+/pmc12130504-157-19-29
Average 90 stars, based on 1 article reviews
Nonlinear Regression Curve Fitting Package (Sigmoidal Dose–Response), supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nonlinear+regression+(curve+fit)-boltzmann+sigmoidal/nonlinear+regression+curve+fitting+package++sigmoidal+dose+response+/pmc12130504-157-19-29
Average 90 stars, based on 1 article reviews
nonlinear regression curve fitting package (sigmoidal dose–response) - by Bioz Stars,
2026-09
90/100 stars
Images
1) Product Images from "Hyperpolarized [1- 13 C]pyruvate NMR spectroscopy reveals transition of tumor energy metabolism in microscale multicellular spheroids"
Article Title: Hyperpolarized [1- 13 C]pyruvate NMR spectroscopy reveals transition of tumor energy metabolism in microscale multicellular spheroids
Journal: Scientific Reports
doi: 10.1038/s41598-025-03454-1
Figure Legend Snippet: IC 50 and IC 90 values (μM) of anti-tumor drugs for monolayer and spheroid-cultured cells in a 96-well format (Fig.
Techniques Used: Cell Culture, MTS Assay, Software
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